Livedo reticularis (LR), commonly known as mottled skin, manifests as a purplish, net-like discoloration on the arms or legs. This pattern often results from reduced blood flow near the skin’s surface and can be triggered by factors like cold temperatures, stress, or certain medications, particularly amantadine, used in treating Parkinson’s disease, multiple sclerosis, and ADHD. The condition is more noticeable in cold weather and typically fades when the skin warms up.

There are two types of LR:

• Primary (Physiological): A benign, temporary reaction to cold, often seen in children, young adults, or individuals with fair skin.
• Secondary (Pathological): A more persistent form linked to underlying health issues such as autoimmune diseases, vascular disorders, or blood clotting abnormalities.

While primary LR usually doesn’t require treatment, secondary LR may necessitate medical intervention, including medications like anticoagulants or corticosteroids, and lifestyle changes such as quitting smoking and managing blood pressure and cholesterol.

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